Matthew, the World No2 from Sheffield, will now face Egyptian maestro Amr Shabana, the four-time world champion who is celebrating a record 16th successive appearance in the Hong Kong Open.
Nearly nine years after making his first appearance in the main draw of a PSA World Series event, Spaniard Borja Golan has made his long-awaited breakthrough into the quarter-finals of one of the PSA Tour's elite championships after upsetting Egypt's No8 seed Mohamed El Shorbagy.
This is Golan's 33rd appearance in a World Series event since earning a place in the 2003 World Open in Pakistan - since when the 29-year-old from Santiago de Compostela reached a career-high world No10 to become Spain's highest-ranked player of all-time.
But he also suffered a career-threatening knee injury in 2009 - resulting in a lengthy layoff which saw him plummet out of the world top 100.
Now just eight places away from his best-ever ranking, Golan stunned eighth seed Mohamed El Shorbagy - beating the world No7 from Egypt 11-6, 11-9, 8-11, 11-9 to become the only unseeded player in the last eight of the sixth PSA World Series event of the year.
"When you play someone like that you have to play more than 100% - you have to fight for each point as if it was the last one," Golan told www.squashsite.com afterwards.
The Spaniard will now line up against top seed James Willstrop after the world number one from England stopped veteran Hong Kong Open campaigner Ong Beng Hee, the 32-year-old Malaysian who made his debut in the event in the 2000 championship, 11-8, 11-9, 11-7 in 68 minutes.
Beng Hee stole the hearts of the Centre Court crowd with a skilful and spirited performance that earned him a standing ovation at the end.
Willstrop is one of three Englishmen who will be in quarter-final action tomorrow. Peter Barker, the No6 seed from London, fought back from 6-10 down in the first game to beat top-ranked Australian Cameron Pilley 13-11, 11-8, 11-8 in 65 minutes.
In the final match of the day - which for the second day in the championship finished well after midnight - second-seeded Englishman Nick Matthew saw off South African Stephen Coppinger 11-6, 11-6, 11-8.
Amr Shabana, the four-time world champion is celebrating a record 16th successive appearance in the Hong Kong Open, but at 0/2 down to unseeded Englishman Tom Richards, it looked as if the 33-year-old from Cairo's bid for a sixth title might be over. But the seventh seed showed why he is still one of the most admired and gifted players when he fought back to take the next three games - and record a sensational 10-12, 10-12, 11-7, 11-7, 11-7 victory in 70 minutes to keep his title hopes alive.
"The best match of the tournament by miles!" tweeted England's Daryl Selby later. "What a game @TomRichards86 played, and great comeback by the ever classy @amrchabana."
It was an upbeat comment which contrasted the world number ten's earlier Twitter pronouncement: "To say I'm disappointed is an understatement..."
Unseeded Selby issued this comment shortly after extending fourth seed Karim Darwish for 65 minutes in a match which ultimately saw the Egyptian prevail 6-11, 11-4, 12-10, 11-6.
"One of my most disappointing days on a squash court today," Selby continued. "Had so much to play for and didn't quite play well enough but still could have won."
Former champion Ramy Ashour became Egypt's third winner of the day when he beat Indian number one Saurav Ghosal 11-7, 11-5, 10-12, 12-10 in 61 minutes.
"Lost a really close 3-1 to Ramy today...12-10 in the 4th!" tweeted world No22 Ghosal later. "Had game balls in the last game as well...good performance though :)"
Gregory Gaultier kept French hopes for success alive when he defeated Swiss number one Nicolas Mueller 11-4, 11-5, 11-5. The third seed from Aix-en-Provence, bidding the reach the final for the fifth time, but win it for the first, now faces Ashour in the pair's 20th Tour clash since December 2005.
PSA World Series Cathay Pacific Sun Hung Kai Financial Hong Kong Open, Hong Kong
 James Willstrop (ENG) bt Ong Beng Hee (MAS) 11-8, 11-9, 11-7 (68m)
Borja Golan (ESP) bt  Mohamed El Shorbagy (EGY) 11-6, 11-9, 8-11, 11-9 (68m)
 Peter Barker (ENG) bt Cameron Pilley (AUS) 13-11, 11-8, 11-8 (65m)
 Karim Darwish (EGY) bt Daryl Selby (ENG) 6-11, 11-4, 12-10, 11-6 (65m)
 Gregory Gaultier (FRA) bt Nicolas Mueller (SUI) 11-4, 11-5, 11-5 (43m)
 Ramy Ashour (EGY) bt Saurav Ghosal (IND) 11-7, 11-5, 10-12, 12-10 (61m)
 Amr Shabana (EGY) bt Tom Richards (ENG) 10-12, 10-12, 11-7, 11-7, 11-7 (70m)
 Nick Matthew (ENG) bt Stephen Coppinger (RSA) 11-6, 11-6, 11-8 (35m)
 James Willstrop (ENG) v Borja Golan (ESP)
 Karim Darwish (EGY) v  Peter Barker (ENG)
 Gregory Gaultier (FRA) v  Ramy Ashour (EGY)
 Nick Matthew (ENG) v  Amr Shabana (EGY)
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